Bromine → HCID 54167733, compound

HRID 1291997Notes

Reaction equation

HRID 1291997 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:11]=[C:10]([O:12][CH:13]([F:15])[F:14])[N:9]([CH3:16])[N:8]=2)[N:5]=[CH:4][C:3]=1[C:17]#[N:18].[Br:19]Br>C(O)(=O)C>[NH2:1][C:2]1[N:6]([C:7]2[C:11]([Br:19])=[C:10]([O:12][CH:13]([F:14])[F:15])[N:9]([CH3:16])[N:8]=2)[N:5]=[CH:4][C:3]=1[C:17]#[N:18]

Participants

4

Reactant 2

HCID 24408BromineHCID 53746681HCID 53746681, compound

Product 1

HCID 54167733HCID 54167733, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.0 g (20 mmol) 5-Amino-1-(5-difluoromethoxy-1-methyl-3-pyrazolyl)-4-pyrazolecarbonitrile was dissolved in 80 ml acetic acid. At room temperature, 1.2 ml (23 mmol) bromine was added, dropwise. After stirring for 15 minutes, the mixture was concentrated and stirred with diisopropyl ether/propanol. The solid material was suction filtered and dried.

Workup

  1. concentrationthe mixture was concentrated
  2. stirringstirred with diisopropyl ether/propanol
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-56a21fe2798e43f09a611ad7756d5dfb
Source dataset
uspto-grants-1998_05
Patent number
US05756424

Reaction notes

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