Ammonia → 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

HRID 1292004Notes

Reaction equation

HRID 1292004 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=O.[NH3:15]>>[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)(=[O:2])[NH2:15]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 537319905-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

Procedure

80.6 g (0.39 mol) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole and 300 ml aqueous ammonia (33%) was stirred for one hour under reflux. The reaction solution was cooled, the precipitate suction filtered off and washed with water and diisopropyl ether.

Workup

  1. temperatureunder reflux
  2. temperatureThe reaction solution was cooled
  3. filtrationthe precipitate suction filtered off
  4. washwashed with water and diisopropyl ether

Sources & evidence

ORD record
ord-316894bd780042158b936889e802f627
Source dataset
uspto-grants-1998_05
Patent number
US05756424

Reaction notes

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