HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → 5-Chloro-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | 5,6,7,8-Tetrahydroquinolin-5-ol | HCID 4598923 | — |
| Product | 5-Chloro-5,6,7,8-tetrahydroquinoline | HCID 18914103 | — |
Reaction Steps
5-Hydroxy-5,6,7,8-tetrahydroquinoline from step 1 above was converted to the chloride using the procedure as given in step 2 of Example 3. The crude 5-chloro-5,6,7,8-tetrahydroquinoline was purified by pressurized silica gel column chromatography using 7:3 EtOAc:hexane as eluant. 5-Chloro-5,6,7,8-tetrahydroquinoline was obtained as a pale yellow oil (TLC Rf = 0.40 (8:2 EtOAc:hexane)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756497 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-f398a21cbf54472fb39850596842c269 |
| Source note | uspto-grants-1998_05 |