反应详情

A mixture of (I) (3.60 g, 13.3 mmol) and excess 85% aqueous hydrazine in ethanol (250 mL) was heated under reflux for 10 minutes (a precipitate formed). After cooling in a freezer overnight, the solid was collected by filtration and dried to give 4-trifluoromethylpyridazino[4,5-b]indolizin-1-one (II, 2.65 g, 79%)

1. temperaturewas heated
2. temperatureunder reflux for 10 minutes (a precipitate
3. customformed)
4. temperatureAfter cooling in a freezer overnight
5. filtrationthe solid was collected by filtration
6. customdried