Hydrazine → HCID 86752611, compound

HRID 1292062Notes

Reaction equation

HRID 1292062 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[N:13]2[C:8]([CH:9]=[CH:10][CH:11]=[CH:12]2)=[CH:7][C:6]=1[C:14](OC)=[O:15])=O.[NH2:20][NH2:21]>C(O)C>[F:1][C:2]([F:19])([F:18])[C:3]1[C:5]2[N:13]3[C:8]([CH:9]=[CH:10][CH:11]=[CH:12]3)=[CH:7][C:6]=2[C:14](=[O:15])[NH:21][N:20]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 18914137HCID 18914137, compound

Product 1

HCID 86752611HCID 86752611, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (I) (3.60 g, 13.3 mmol) and excess 85% aqueous hydrazine in ethanol (250 mL) was heated under reflux for 10 minutes (a precipitate formed). After cooling in a freezer overnight, the solid was collected by filtration and dried to give 4-trifluoromethylpyridazino[4,5-b]indolizin-1-one (II, 2.65 g, 79%)

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 10 minutes (a precipitate
  3. customformed)
  4. temperatureAfter cooling in a freezer overnight
  5. filtrationthe solid was collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-6355edc7f834451f8e7e42803161cd21
Source dataset
uspto-grants-1998_05
Patent number
US05756501

Reaction notes

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