Acetic Acid → HCID 18914135, compound

Participants

Reaction Steps

4-(Methyl)-N,N-diethyl-N'-[pyridazino[4,5-b]indolizin-1-yl]-1,3-propanediamine (2.75 g, 8.83 mmoL) was hydrogenated in a Parr appartus with 10% Pd on charcoal (0.54 g) in a 1:1 mixture of acetic acid and methanol at 55 psi and room temperature. Filtration through Solka Floc to remove the catalyst and evaporation of the filtrate gave a crude product which was passed through a pad of alumina eluting with 5% methanol in methylene chloride to give the free base of the title product in quantitative yield. The free base was converted to the monofumarate salt: m.p.171°-172° C.

Provenance & Evidence