3-Azabicyclo[3.2.2]nonane-3-propanamine → N-[3-(3-Azabicyclo[3.2.2]non-3-yl)propyl]-6,7,8,9-tetrahydro-4-(methyl)pyridazino[4,5-b]indolizin-1-amine

HRID 1292071Notes

Reaction equation

HRID 1292071 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[C:9]3[N:14]([C:6]=2[C:5]([CH3:15])=[N:4][N:3]=1)[CH2:13][CH2:12][CH2:11][CH2:10]3.[CH:16]12[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]1)[CH2:19][N:18]([CH2:25][CH2:26][CH2:27][NH2:28])[CH2:17]2>>[CH:20]12[CH2:23][CH2:24][CH:16]([CH2:22][CH2:21]1)[CH2:17][N:18]([CH2:25][CH2:26][CH2:27][NH:28][C:2]1[N:3]=[N:4][C:5]([CH3:15])=[C:6]3[N:14]4[C:9]([CH2:10][CH2:11][CH2:12][CH2:13]4)=[CH:8][C:7]=13)[CH2:19]2

Participants

3

Reactant 2

HCID 135110803-Azabicyclo[3.2.2]nonane-3-propanamineHCID 867526161-Chloro-4-methyl-6,7,8,9-tetrahydropyridazino[4,5-b]indolizine

Product 1

HCID 18914143N-[3-(3-Azabicyclo[3.2.2]non-3-yl)propyl]-6,7,8,9-tetrahydro-4-(methyl)pyridazino[4,5-b]indolizin-1-amine

Procedure

Following the procedure in Example 9, compound XII was allowed to react with 3-(3-azabicyclo[3.2.2]non-3-yl)propylamine to give the title compound which was converted to the dihydrochloride salt: m.p.278°-279° C.

Sources & evidence

ORD record
ord-93d2014f890e428f90fbaf145b9835b9
Source dataset
uspto-grants-1998_05
Patent number
US05756501

Reaction notes

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