Hydrochloric Acid → HCID 86752617, compound

Participants

Reaction Steps

To a solution of 3-{3-[3-(3-Isopropoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-ureido}-benzoic acid ethyl ester (200 mg, 0.41 mmol) in 1,4-dioxane (10 mL) was added 1N LiOH (3 mL) and stirred overnight. The reaction mixture was acidified with 1N HCl and concentrated. It was then diluted with ethyl acetate and washed with water. The organic layer was dried over MgSO4, concentrated and chromatographed using ethyl acetate:hexane (1:1 v/v) to isolate pure product as a white solid (150 mg, 80.2%), mp 158°-160° C. Analysis calculated for C25H22 N4O5 : C, 65.49; H, 4.84; N, 12.22. Found: C, 65.49; H, 4.84; N, 12.03.

Provenance & Evidence