HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylparaben → 1-[4-(4-Fluorobenzyloxy)benzoyl]-4-isobutylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | 4-(4-Fluoro-benzyloxy)-benzoic acid | HCID 961595 | — |
| Reactant | 1-(2-Methylpropyl)piperazine | HCID 2052052 | — |
| Product | 1-[4-(4-Fluorobenzyloxy)benzoyl]-4-isobutylpiperazine | HCID 18914222 | 58.4% |
Reaction Steps
It was synthesized in the manner identical to Example 3. Namely, ethyl 4-hydroxybenzoate (2.50 g) was benzylated with 4-fluorobenzyl bromide (2.84 g) and then hydrolyzed. From thus obtained 3.57 g of 4-(4-fluorobenzyloxy) benzoic acid, 1.24 g was subjected to a condensation reaction with 1-isobutylpiperazine (0.71 g), thereby yielding 1.08 g of the aimed compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756505 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-4e9d99ad29fd4b6582547c489d922c2d |
| Source note | uspto-grants-1998_05 |