2-Methyl-1-(piperazin-1-yl)propan-1-one → HCID 18914227, compound

HRID 1292104Notes

Reaction equation

HRID 1292104 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][O:7][C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][C:9]=2[CH2:17][CH:18]([CH3:20])[CH3:19])=[CH:4][CH:3]=1.[C:23]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)(=[O:27])[CH:24]([CH3:26])[CH3:25]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:16]=[CH:15][C:11]([C:12]([N:31]3[CH2:32][CH2:33][N:28]([C:23](=[O:27])[CH:24]([CH3:25])[CH3:26])[CH2:29][CH2:30]3)=[O:14])=[CH:10][C:9]=2[CH2:17][CH:18]([CH3:20])[CH3:19])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 27614092-Methyl-1-(piperazin-1-yl)propan-1-oneHCID 15383033HCID 15383033, compound

Product 1

HCID 18914227HCID 18914227, compoundYield 90%

Procedure

As in the case of Example 16, 4-(4-fluorobenzyloxy)-3-isobutylbenzoic acid (1.51 g) was subjected to a condensation reaction with 1-isobutyrylpiperazine (0.78 g). Thus obtained solid was recrystallized (from ether) to yield 1.98 g of the aimed compound.

Workup

  1. customThus obtained solid was recrystallized (from ether)

Sources & evidence

ORD record
ord-c9336fa0faea4e2dae26665bd298f06b
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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