4-Methoxybenzyl bromide → HCID 18914226, compound

HRID 1292108Notes

Reaction equation

HRID 1292108 reaction equation
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22].[CH3:24][O:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30]Br)=[CH:28][CH:27]=1>>[CH2:14]([N:11]1[CH2:10][CH2:9][N:8]([C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([O:1][CH2:30][C:29]3[CH:32]=[CH:33][C:26]([O:25][CH3:24])=[CH:27][CH:28]=3)=[C:3]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH:4]=2)[CH2:13][CH2:12]1)[CH:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 1650214-Methoxybenzyl bromideHCID 18914218HCID 18914218, compound

Product 1

HCID 18914226HCID 18914226, compoundYield 82.4%

Procedure

As in the case of Example 18, 1-(4-hydroxy-3-isobutylbenzoyl)-4-isobutylpiperazine (1.59 g) was benzylated with 4-methoxybenzyl bromide (0.94 g), thereby yielding 1.69 g of the aimed compound.

Sources & evidence

ORD record
ord-a656b24a93a64f1aa927fafefaa829c4
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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