1-(Bromomethyl)-4-chlorobenzene → HCID 18914215, compound

HRID 1292111Notes

Reaction equation

HRID 1292111 reaction equation
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22].[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Br)=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][O:1][C:2]2[CH:19]=[CH:18][C:5]([C:6]([N:8]3[CH2:9][CH2:10][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:13]3)=[O:7])=[CH:4][C:3]=2[CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 18914218HCID 18914218, compound

Product 1

HCID 18914215HCID 18914215, compoundYield 42.9%

Procedure

As in the case of Example 18, 1-(4-hydroxy-3-isobutylbenzoyl)-4-isobutylpiperazine (1.59 g) was benzylated with 4-chlorobenzyl bromide (1.03 g), thereby yielding 0.95 g of the aimed compound.

Sources & evidence

ORD record
ord-f9af31f653d14c14bf3af186b8fcdc42
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

Loading…