Oxalic Acid → HCID 18914231, compound

HRID 1292115Notes

Reaction equation

HRID 1292115 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:16][CH2:15]3)=[O:13])=[CH:10][C:9]=2[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:4][CH:3]=1.[C:32]([OH:37])(=[O:36])[C:33]([OH:35])=[O:34]>C(OCC)C>[C:32]([OH:37])(=[O:36])[C:33]([OH:35])=[O:34].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH:21]([CH3:22])[CH3:23])[CH2:16][CH2:15]3)=[O:13])=[CH:10][C:9]=2[CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 9888723HCID 9888723, compound

Product 1

HCID 18914231HCID 18914231, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1-[4-(4-fluorobenzyloxy)-3-isobutylbenzoyl]-4-isobutylpiperazine (1.01 g) was dissolved in diethyl ether (10 ml) and then 10 ml of a diethyl ether solution containing oxalic acid (0.4 g) was added thereto. After this mixture was stirred for 10 minutes at room temperature, the resulting crystals were collected by filtration and then recrystallized (from n-hexane/ethanol), thereby yielding 0.93 g of the aimed compound.

Workup

  1. additionwas added
  2. filtrationthe resulting crystals were collected by filtration
  3. customrecrystallized (from n-hexane/ethanol)

Sources & evidence

ORD record
ord-0bc1a29a074747ecbe58d8b1b1107c10
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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