1-(Bromomethyl)-2,4-difluorobenzene → HCID 18914223, compound

HRID 1292117Notes

Reaction equation

HRID 1292117 reaction equation
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22].[F:24][C:25]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:26]=1[CH2:27]Br>>[F:24][C:25]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:26]=1[CH2:27][O:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:13]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 18914218HCID 18914218, compound

Product 1

HCID 18914223HCID 18914223, compoundYield 74.8%

Procedure

As in the case of Example 18, 1-(4-hydroxy-3-isobutylbenzoyl)-4-isobutylpiperazine (1.60 g) was benzylated with 2,4-difluorobenzyl bromide (1.24 g), thereby yielding 1.67 g of the aimed compound.

Sources & evidence

ORD record
ord-212d937b681a40d99ad5fa658c73806a
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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