HCID 10422857, compound → HCID 15411306, compound

HRID 1292155Notes

Reaction equation

HRID 1292155 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O.[NH2:21][C:22]1[CH:32]=[CH:31][C:25]2[NH:26][C:27](=[O:30])[CH2:28][S:29][C:24]=2[CH:23]=1>CCO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[N:21][C:22]1[CH:32]=[CH:31][C:25]2[NH:26][C:27](=[O:30])[CH2:28][S:29][C:24]=2[CH:23]=1

Participants

4

Reactant 2

HCID 10422857HCID 10422857, compoundHCID 126274197-Amino-2H-1,4-benzothiazin-3(4H)-one

Product 1

HCID 15411306HCID 15411306, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A liquid mixture of 1.316 g (5 mmol) of 3-(2-quinolinylmethoxy)benzaldehyde, 0.901 g (5 mmol) of 7-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one and 70 ml of EtOH was heated under reflux and stirring for 24 hours. The mixture was then allowed to cool down. The precipitate was collected by filtration, whereby 1.969 g of the title compound were obtained as pale yellow powder (yield: 92.3%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureto cool down
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-f6f9d2bcfcfd441b9c772c7da617363c
Source dataset
uspto-grants-1998_05
Patent number
US05756518

Reaction notes

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