HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → HCID 86752624, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-(Chloromethyl)pyridine | HCID 18358 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 86752624 | HCID 86752624 | — |
| Product | HCID 86752624 | HCID 86752624 | — |
| Product | HCID 86752625 | HCID 86752625 | — |
Reaction Steps
The title compound is prepared by reaction of glyoxylic acid-O-2-[1-(3-pyridylmethyl)-5-(thiazol-2-ylmethoxy)-2-methylindol-3-yl]ethyl oxime with trifluoroacetic acid to remove the t-BOC group followed by reaction of the indole intermediate with two equivalents of 3-pyridylmethyl chloride in the presence of a suitable base such as NaH to provide the intermediate glyoxylic acid 3-pyridyl ester-O-2-[1-(3-pyridylmethyl)-5-(thiazol-2-ylmethoxy)-2-methylindol-3-yl]ethyl oxime which is subsequently saponified.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756531 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-9b38ba44fae345fda221da9f8c8c24bc |
| Source note | uspto-grants-1998_05 |