HCID 19372784, compound → HCID 19372799, compound

Participants

Reaction Steps

Methyl magnesium bromide (1M THF solution 8 equivalents) was allowed to react with a solution of 3,4-dihydro-4-trifluoroacetylamino-1-(2,4,6-triisopropylphenylsulfonyl)-5H-benz[cd]indol-5-one (1.5 g, 1.43 mmol) in THF (14.3 ml). The reaction mixture was processed in a conventional manner. The residue was subjected to silica gel column chromatography, eluting with n-hexane-ethyl acetate (4:1) to afford 1.3 g (84%) of the title compound as an amorphous crystalline product.

Provenance & Evidence