Nimesulide → HCID 131720676, compound

Participants

Reaction Conditions

Reaction Steps

3 g of nimesulide (9.73×10-3 mole) are suspended in 200 ml of distilled water to which 3.2 g of L-lysine (1.95×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 13.88 g of γ-CD·7H2O (9.73×10-3 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of γ-CD is added to the suspension of nimesulide+L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained. This solution is nebulized (Niro Atomizer Mobile atomizer) in the following conditions:

Provenance & Evidence