HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-((1-(Tert-butoxycarbonyl)piperidin-4-YL)oxy)-2-methoxybenzoic acid | HCID 10545874 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Methoxy-4-(4-piperidyloxy)benzoic acid | HCID 18914167 | — |
Reaction Steps
2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756504 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-f036814dc39d4a55a79d10b483490ec1 |
| Source note | uspto-grants-1998_05 |