HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid | HCID 18914145 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride | HCID 18914181 | — |
Reaction Steps
2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid (0.546 g, 1.86 mmol) in THF (10 ml) was stirred under nitrogen and treated with thionyl chloride (0.27 ml, 0.44 g, 3.7 mmol). The mixture was stirred at ambient temperature for 18 hours, then concentrated in vacuo to give 2-methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756504 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-bb3521b71abe4b33bb12b5b60ad74aa5 |
| Source note | uspto-grants-1998_05 |