反应详情

To a stirred solution of 2-(3,5-dimethylphenylethynyl)-4-nitrophenylamine (50 mg in 3 mL of dry, nitrogen saturated acetonitrile) was added 5 mg of palladium (II) chloride and the mixture heated to reflux on an oil bath. After 3 hours the mixture was cooled to room temperature, concentrated in vacuo and purified by flash chromatography on silica gel (hexane:methylene chloride:ethyl acetate 15:8:1) to provide the title compound (46 mg).

1. temperaturethe mixture heated
2. temperatureto reflux on an oil bath
3. concentrationconcentrated in vacuo
4. custompurified by flash chromatography on silica gel (hexane:methylene chloride:ethyl acetate 15:8:1)