[2-(4-Benzyloxyphenyl)-ethyl]-carbamic acid 4-nitrophenyl ester → 1-[2-(4-benzyloxyphenyl)ethyl]-3-{2-[2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}urea

関与物質

反応手順

To a solution of 2-[2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethylamine (EXAMPLE 2 Step D, 39 mg in 1 mL dry methanol) was added 64 mg [2-(4-benzyloxyphenyl)-ethyl]-carbamic acid 4-nitrophenyl ester and the mixture stirred at room temperature. After 24 hours, the mixture was concentrated in vacuo and the residue re-solvated in ethyl acetate. This was washed with saturated aqueous potassium carbonate (3×) and brine, dried over sodium sulfate and purified by flash chromatography on silica gel (hexane:ethyl acetate, 5:4; then 1:1) to give the title compound (73 mg).

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