Acetic Acid → HCID 18914246, compound

Participants

Reaction Steps

To 2.53 g glacial acetic acid was added 2.0 g dimethyl amine (40% aqueous solution) followed by 1.37 g fomalin (37% solution) then 4.0 g 2-(3,5-dimethylphenyl)-1H-indole and the mixture stirred at 0° C. After 15 minutes, 40 mL ethanol was added and the mixture allowed to warm to room temperature. After 1 hour at room temperature, the reaction was quenched by pouring into 50 mL of 1N sodium hydroxide. The resulting mixture was extracted with methylene chloride (4×10 mL) and the combined organics dried over potassium carbonate. Concentration in vacuo gave the crude title compound (4.15 g).

Provenance & Evidence