HCID 18914251, compound → HCID 18914267, compound

Participants

Reaction Steps

To a solution of 1-[2-(3,5-dimethylphenyl)-1H-indol-3-yl]-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione (57 mg in 2 mL dry tetrahydrofuran) was added 30 mg of lithium aluminum hydride and the mixture heated to reflux on an oil bath. After 1 hour the mixture was cooled and quenched by the sequential addition of 1 mL water and 4 mL ammonium hydroxide and 5 mL ethyl acetate. The mixture was filtered to remove the solids. The organic portion was washed with brine, dried over magnesium sulfate and the concentrate purified by flash chromatography on silica gel (ethyl acetate:hexane, 1:5) to give the title compound (38 mg). m/e=410 (M+1)

Provenance & Evidence