HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,4-Dichlorophenyl)acetyl chloride → 1-(3,4-Dichlorophenylacetyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,4-Dichlorophenyl)acetyl chloride | HCID 2758149 | — |
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(3,4-Dichlorophenylacetyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915024 | 127.3% |
Reaction Steps
The procedure described in Example 17, but using 1.0 g of 1-methyl-3-(pyrrolidin-1-ylmethyl )piperazine trihydrochloride, 2.1 ml of triethylamine and 0.8 g of 3,4-dichlorophenylacetyl chloride, to afford 1.01 g of the title compound, melting at 223°-227° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-61838fc6f5ce4fc8a5504550a6049175 |
| Source note | uspto-grants-1998_05 |