HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride → 4-Methyl-1-(3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Reactant | 3-Oxoindan-1-carbonyl chloride | HCID 21820519 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-Methyl-1-(3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915149 | 31.9% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 3.21 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 6.9 ml of triethylamine and 4.5 g of 3-oxoindan-1-carbonyl chloride, to afford 1.45 g of the title compound, melting at 252°-255° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-1797d2e9daf74c999c5c2f41f6d45b7f |
| Source note | uspto-grants-1998_05 |