HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride → 1-(6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride | HCID 15342871 | — |
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915130 | 108.3% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 1.0 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 2.1 ml of triethylamine and 1.0 g of 6,7-dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride, to afford 0.97 g of the title compound, melting at 275°-278° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-b4fc0747ff694592a845442080d8ffd0 |
| Source note | uspto-grants-1998_05 |