HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride → 1-(6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride | HCID 15342870 | — |
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915147 | 111.1% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 1.0 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 2.1 ml of triethylamine and 0.87 g of 6-chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride, to afford 0.92 g of the title compound, melting at 268°-274° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-078ac2b7e6654cd793403b53b5c0ca53 |
| Source note | uspto-grants-1998_05 |