HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride → 4-(6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride | HCID 15342870 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)thiomorpholine | HCID 15730147 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(6-Chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride | HCID 18915156 | 132.8% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 1.0 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 1.38 ml of triethylamine and 1.5 g of 6-chloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride, to afford 1.76 g of the title compound, melting at 195°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-64978cc370434448a3562fbc992e5f8e |
| Source note | uspto-grants-1998_05 |