HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride → 4-(6,7-Dichloro 1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-3-(piperidinomethyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,7-Dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride | HCID 15342871 | — |
| Reactant | 3-(Piperidinomethyl)thiomorpholine | HCID 18915121 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(6,7-Dichloro 1,2,3,4-tetrahydro-4-oxo-1-naphthoyl)-3-(piperidinomethyl)thiomorpholine hydrochloride | HCID 18914983 | 121.1% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 2.0 g of 3 -(piperidinomethyl)thiomorpholine, 2.2 ml of triethylamine and 3.52 g of 6,7-dichloro-1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride, to afford 3.67 g of the title compound, melting at 245°-254° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756730 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-c985a6b77cd6494a8b4fe12f11c3f73c |
| Source note | uspto-grants-1998_05 |