Chlorodifluoromethane → 4-Difluoromethyl-3-methyl-1-phenyl-1H-1,2,4-triazol-5(4H)-one

Participants

Reaction Steps

This compound was prepared in the manner of Example 1, with 25.0 grams of 4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-1,2,4-triazole (0.110 mole--1.0 equiv.), 30.0 grams (0.217 mole--2.0 equiv.) of potassium carbonate, and 14.3 grams (0.165 mole--1.5 equiv.) of chlorodifluoromethane in 220 mL of polyglyme (% wt/vol. triazole to solvent--11%) as reagents. A yield of 28.7 grams of 91.5% pure 4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-1,2,4-triazole (87.8% yield) was obtained. GC analysis of the product indicated the presence of about 5.0% O-isomer by-product.

Provenance & Evidence