HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-[[2-(4-Morpholinyl)ethyl]methylamino]-1,2-benzisoxazol-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 6-Methoxy-N-methyl-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine | HCID 15816925 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 3-[[2-(4-Morpholinyl)ethyl]methylamino]-1,2-benzisoxazol-6-ol | HCID 135815058 | 90% |
Reaction Steps
6-Methoxy-N-methyl-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine (7.0 g) was dissolved in 48% hydrobromic acid (130 ml) and heated to reflux under nitrogen for 3 hours. The reaction was cooled to room temperature, neutralized with saturated sodium carbonate (Na2CO3) extracted with ethyl acetate, dried over MgSO4 and concentrated in vacuo. Flash chromatography (silica gel) eluting with 2:1 heptane/acetone provided the product (6.0 g), m.p. 91°-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756754 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-73c4446743dd46c8a55dfb54aee7cf58 |
| Source note | uspto-grants-1998_05 |