O-Xylene → 2-Cyano-4'-methylbiphenyl

Participants

Reaction Steps

15 g of 2-chlorobenzonitrile, 14.8 g of p-tolueneboronic acid and 28.9 g of sodium carbonate were heated to 120° C. in 40 ml of glycol and 10 ml of water. At 80° C., 0.1 mol % of a catalyst solution prepared as described in C.4 was added. After the reaction was complete, 50 ml of xylene were added and the organic phase was separated off. Distillation gave 18.1 g of 2-cyano-4'-methylbiphenyl (mp. 140° C./mbar).

Provenance & Evidence