Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | Isobutyl methanephosphonite | HCID 86741778 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Product | HCID 178454800 | HCID 178454800 | 83% |
Reaction Steps
A mixture of 50.0 g (289 mmol) of 4-bromofluorobenzene, 43.3 g (318 mmol) of isobutyl methanephosphonite, 43.8 ml (318 mmol) of triethylamine, 1.64 g (0.29 mmol,1 mol %) of bis(dibenzylideneacetone)-palladium and 1.50 g (0.58 mmol, 2 mol %) of triphenylphosphine was heated for 20 hours at 100° C. under an inert gas atmosphere. At 23° C., the solution was filtered off from the ammonium salt formed and the filtrate was evaporated under reduced pressure. Fractional distillation under reduced pressure gave 54.60 g (83% of theory) of isobutyl 4-fluorophenylmethylphosphinate having a boiling point of 83° C./0.08 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05756804 |
|---|
| Source dataset | uspto-grants-1998_05 |
|---|
| ORD ID | ord-e6f2a48747eb4053b2d23e3f6f939382 |
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| Source note | uspto-grants-1998_05 |
|---|
