Toluene → Benzoic acid, 2-fluoro-4-hydroxy-, 6-ethoxy-1-(trifluoromethyl)hexyl ester

Participants

Reaction Steps

A reactor was charged with 1 g of 4-acetoxy-2-fluoro-1-(6-ethoxy-1-trifluoromethylhexyloxy-carbonyl)benzene (formula (1); X=F, Y=--CF3, Q=--CH3, m=1, p=5, n=2), 15 ml of toluene and 0.5 g of a methanol solution containing 40 wt% methylamine, and the mixture is stirred at room temperature for 15 minutes. After the reaction, the reaction mixture was washed with a 4 wt% hydrochloric acid aqueous solution and then with water to separate an organic layer from the solution. The organic layer was dried over anhydrous sodium sulfate, and then, the solvent is distilled off to give 4-hydroxy-2-fluoro-1-(6-ethoxy-1-trifluoromethylhexyloxy-carbonyl)benzene (formula (2); X=F, m=1, p=5, n=2). This product was dissolved in acetone and analyzed by gas chromatography to show no presence of methylacetamide (CH3CONHCH3).

Provenance & Evidence