Nitric Acid → 5-Fluoro-2-nitrobenzoic acid

Participants

Reaction Steps

841 g of 3-fluorobenzoic acid were placed in 3261 g of 100% strength by weight sulphuric acid and the mixture was cooled to +10° C. 1147 g of nitrating acid comprising 67% by weight of 100% strength by weight sulphuric acid and 33% by weight of 100% strength by weight nitric acid were then added. After the reaction was completed, the mixture contained approximately 1.65% by weight of wrong isomers. The mixture was added to 10 1 of water and then cooled to room temperature. The solid product precipitated out was filtered off and then washed 3 times, each time with 2 1 of water, and dried. 957.8 g of 5-fluoro-2-nitro-benzoic acid (calculated as 100% pure product) were obtained, which corresponds to 86.3% of theory. The product contained 0.17% by weight of 3-fluoro-2-nitro-benzoic acid.

Provenance & Evidence