(+-)-Aspartic Acid → Ammonia
Reaction equation
[NH2:1][CH:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[NH2:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][C:13]([OH:15])=[O:14]>>[NH2:1][CH:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[C:16]([OH:18])(=[O:17])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14].[NH3:10]Participants
5
Procedure
We have found that this object is achieved by a process for preparing D,L-aspartic acid by heating aqueous solutions of ammonium salts of aspartic acid at elevated temperatures under pressure, acidifying the reaction solution to liberate D,L-aspartic acid and isolating the D,L-aspartic acid, when maleic acid and ammonia are reacted in a molar ratio of from 1:2.1 to 1:50 in aqueous solution at from 60° C. to 250° C. under pressures of at least 1 bar, the pressure being controlled during the reaction in such a way that the reaction mixture is almost entirely in the liquid phase.
Sources & evidence
- ORD record
- ord-15ac92a9207441cfb4d50dd50cfcb7ca
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05756839
Reaction notes
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