Ammonia → (+-)-Aspartic Acid

HRID 1292622Notes

Reaction equation

HRID 1292622 reaction equation
[NH3:1].[C:2]([OH:9])(=[O:8])/[CH:3]=[CH:4]\[C:5]([OH:7])=[O:6]>O>[NH2:1][CH:3]([C:2]([OH:9])=[O:8])[CH2:4][C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 444266Maleic Acid

Product 1

HCID 424(+-)-Aspartic AcidYield 95.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

The mother liquor and the washing water from Example 11 are combined. Then water and ammonia are added until 2780 ml of a 20% strength aqueous solution with a pH of 10.5 are obtained. This solution is reacted as described in Example 9 and subsequently concentrated as in Example 10. 1453 ml of a bottom product remain. D,L-aspartic acid is then precipitated as described in Example 11 by adding 323 g (2.78 mol) of maleic acid. Drying results in 382 g (2.87 mol) of D,L-aspartic acid, corresponding to a yield of 95.7% based on the amount of maleic acid added in Example 11.

Workup

  1. customare obtained
  2. customThis solution is reacted
  3. concentrationsubsequently concentrated as in Example 10
  4. customD,L-aspartic acid is then precipitated
  5. customDrying

Sources & evidence

ORD record
ord-b3ff85da8a8b4913bec42b1648479477
Source dataset
uspto-grants-1998_05
Patent number
US05756839

Reaction notes

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