Methyl chloroformate → HCID 57463856, compound

Participants

Reaction Steps

To a solution of the product of Example 2 (40 mg, 0.083 mmol) in CH2 Cl2 (1 ml) and triethylamine (24 μl, 0.17 mmol) at 0° C. was added methyl chloroformate (39 μl of a 2.1M solution in CH2 Cl2, 0.082 mmol). The reaction was stirred at room temperature for 3 hr, the solvent evaporated in vacuo and the residue purified by preparative HPLC (C-18; 95:5 to 5:95 water:CH3CN containing 0.1% trifluoroacetic acid; gradient elution). Lyophilisation of the collected fractions afforded the title compound as a white solid.

Provenance & Evidence