2-(Methylamino)ethanol → HCID 69413756, compound

HRID 1292701Notes

Reaction equation

HRID 1292701 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.O1CCOCC1.[CH3:19][NH:20][CH2:21][CH2:22][OH:23]>O>[CH3:12][O:11][C:4]1[N:3]=[C:2]([CH2:19][NH:20][CH2:21][CH2:22][OH:23])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 80162-(Methylamino)ethanolHCID 312751,4-DioxaneHCID 27950292-Chloro-6-methoxy-3-nitropyridine

Product 1

HCID 69413756HCID 69413756, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.9 g (0.01 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 30 ml of dioxane, 5 ml of water and 1.6 ml (0.02 mol) of 2-methylaminoethanol are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 1.6 g of yellow powder are obtained, ie a yield of 70%.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. stirringwith stirring
  3. customThe precipitate formed
  4. filtrationis filtered off by suction
  5. customdried under vacuum to constant weight

Sources & evidence

ORD record
ord-8aa1143c18124e82a60df5635239728c
Source dataset
uspto-grants-2007_07
Patent number
US07238211B2

Reaction notes

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