Acetaldehyde → HCID 58904498, compound

HRID 1292747Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([O:9][C@@H:10]([C@@:14]2([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[NH:20][CH2:19][C:18](=[O:21])[N:17]([CH3:22])[C:16]3[CH:23]=[CH:24][CH:25]=[CH:26][C:15]2=3)[C:11]([OH:13])=[O:12])[N:3]=1.[CH:33](=O)[CH3:34]>>[CH2:33]([N:20]1[C@@:14]([C@H:10]([O:9][C:4]2[N:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[N:5]=2)[C:11]([OH:13])=[O:12])([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:15]2[CH:26]=[CH:25][CH:24]=[CH:23][C:16]=2[N:17]([CH3:22])[C:18](=[O:21])[CH2:19]1)[CH3:34]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 10224745HCID 10224745, compound

Product 1

HCID 58904498HCID 58904498, compound

Procedure

(±)-(S*)-((5S*)-4-ethyl-1-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl)-(4,6-dimethyl-pyrimidin-2-yloxy)-acetic acid is prepared starting from (±)-(S*)-((5S*)-1-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl)-(4,6-dimethyl-pyrimidin-2-yloxy)-acetic acid (Example 49) and acetaldehyde in analogy to Example 127. LC-MS1: tR=0.75 min, [M+1]+=461.16.

Sources & evidence

ORD record: ord-57be14260bfb4828a7d029e7afdc920f
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238685B2

Reaction notes

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