Trifluoroacetic acid → 4-(Carboxymethoxy)-benzoic acid 1-methyl ester

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Reaction Steps

To a solution of 4-tert-butoxycarbonylmethoxy-benzoic acid methyl ester (5 g, 18.8 mmol) in dry DCM (40 ml) is added trifluoro-acetic acid (40 ml) at 0° C. The solution is stirred for 5 h at rt and evaporated in vacuo to give 4-carboxymethoxy-benzoic acid methyl ester 4 g as a white solid. LC-MS2: tR=3.24 min, [M+1]+=211.04, [M−1]−=208.96.

Provenance & Evidence