HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,4-Dichlorophenoxy)piperidine → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,4-Dichlorophenoxy)piperidine | HCID 3732042 | — |
| Reactant | Tert-butyl 2-(((methylsulfonyl)oxy)methyl)morpholine-4-carboxylate | HCID 57791474 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ammonia | HCID 222 | — |
| Product | tert-Butyl 2-{[4-(3,4-dichlorophenoxy)piperidin-1-yl}methyl]morpholine-4-carboxylate | HCID 17974804 | — |
Reaction Steps
To a solution of the product from Example 1, Step (b) dissolved in acetonitrile (12 ml) was added the product of Example 2, Step (a). The mixture was refluxed for 12 hrs and the solvents were evaporated. Purification by flash chromatography (silica) eluting with dichloromethane: methanol: NH3 (aq) (2:98:0.1) gave the sub-title compound as an oil (1.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238691B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-035fcec48b814741adcef02eb7c64b74 |
| Source note | uspto-grants-2007_07 |