1-(Hex-5-ynyl)-4-phenyl-2-oxa-6,7-dithiabicyclo[2.2.2]octane → 1-(Hex-5ynyl)-4-n-propyl-2-oxa-6,7-dithiabicyclo[2.2.2]octane

Participants

Role	Name	HCID	Charge
Reactant	1-(Hex-5-ynyl)-4-phenyl-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373265	—
Reactant	4-i-Butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373267	—
Reactant	2-n-Butyl-2-hydroxymethylpropan-1,3-dithiol	HCID 19373279	—
Reactant	4-t-Butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373308	—
Reactant	4-n-Butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373313	—
Reactant	2-Hydroxy-methyl-2-phenylpropan-1,3-dithiol	HCID 19373331	—
Reactant	2-t-Butyl-2-hydroxymethylpropan-1,3-dithiol	HCID 19373398	—
Reactant	4-Cyclopropylmethyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373402	—
Reactant	2-i-Butyl-2-hydroxymethylpropan-1,3-dithiol	HCID 23172590	—
Reactant	2-Cyclopropylmethyl-2-hydroxymethylpropan-1,3-dithiol	HCID 53750044	—
Product	1-(Hex-5ynyl)-4-n-propyl-2-oxa-6,7-dithiabicyclo[2.2.2]octane	HCID 19373338	—

Reaction Steps

In an analogous manner 4-n-butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane, 4-t-butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane, 4-i-butyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane, 1-(hex-5-ynyl)-4-phenyl-2-oxa-6,7-dithiabicyclo[2.2.2]octane and 4-cyclopropylmethyl-1-(hex-5-ynyl)-2-oxa-6,7-dithiabicyclo[2.2.2]octane were prepared from trimethyl orthohept-6-ynoate and 2-n-butyl-2-hydroxymethylpropan-1,3-dithiol, 2-t-butyl-2-hydroxymethylpropan-1,3-dithiol, 2-i-butyl-2-hydroxymethylpropan-1,3-dithiol, 2-hydroxy-methyl-2-phenylpropan-1,3-dithiol and 2-cyclopropylmethyl-2-hydroxymethylpropan-1,3-dithiol respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05466710
Source dataset	uspto-grants-1995_11
ORD ID	ord-2709eb2110a746aeae8a62332b09c528
Source note	uspto-grants-1995_11