HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline | HCID 58820195 | — |
| Product | 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine | HCID 58905130 | — |
Reaction Steps
Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238698B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-9a55840aab77422bbbf1d8a693a522b8 |
| Source note | uspto-grants-2007_07 |