Propargyl alcohol → 3-(Prop-2-yn-1-yloxy)propanoic acid

HRID 129289Notes

Reaction equation

C(O)C#C.BrCCC(OCC)=O.[CH2:13]([O:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH2:14][C:15]#C>>[CH2:13]([O:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[C:14]#[CH:15]

Participants

Reactant 3

HCID 7859Propargyl alcohol

HCID 68320Ethyl 3-bromopropionate

HCID 193734123-(But-3-yn-1-yloxy)propanoic acid

Product 1

HCID 2879343-(Prop-2-yn-1-yloxy)propanoic acid

Procedure

3-(Prop-2-ynyloxy)propionic acid was prepared from propargyl alcohol and ethyl 3-bromopropionate using methodology analogous to that describing the synthesis of 3-(but-3-yn-1-yloxy)propionic acid (Example XIX).

Sources & evidence

ORD record: ord-027b8ecf9daf47968bfa795a03b5d926
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05466710

Reaction notes

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