Ammonia → HCID 86593174, compound

HRID 1292925Notes

Reaction equation

HRID 1292925 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:16]4=[C:17]([C@@H:19]5[CH2:24][NH:23][CH2:22][CH2:21][C@@H:20]5[N:15]4[CH2:14][CH2:13][CH2:12]3)[CH:18]=2)=[C:5]([C:25]([F:28])([F:27])[F:26])[CH:4]=1.Br[CH2:30][CH:31]([F:33])[F:32].N>>[F:32][CH:31]([F:33])[CH2:30][N:23]1[CH2:22][CH2:21][C@@H:20]2[N:15]3[C:16]4[C:11](=[CH:10][C:9]([C:6]5[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=5[C:25]([F:28])([F:26])[F:27])=[CH:18][C:17]=4[C@@H:19]2[CH2:24]1)[CH2:12][CH2:13][CH2:14]3

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1361862-Bromo-1,1-difluoroethaneHCID 59012632HCID 59012632, compound

Product 1

HCID 86593174HCID 86593174, compound

Procedure

The title compound was prepared by the method of Example 382 as a yellow oil (27 mg, 77%) from (7aS,11aR)-2-[4-methoxy-2-(trifluoromethyl)phenyl]-5,6,7a,8,9,10,11,11a-octahydro-4H-pyrido[3′,4′:4,5]pyrrolo[3,2,1-ij]quinoline (30 mg, 0.077 mmol) and 2-bromo-1,1-difluoroethane (35 mg, 0.23 mmol). MS (CI, NH3): 453.1 (base, M+H).

Sources & evidence

ORD record
ord-7156c237775445cead485b280027a66d
Source dataset
uspto-grants-2007_07
Patent number
US07238690B2

Reaction notes

Loading…