Phenylboronic Acid → HCID 68889039, compound

Participants

Reaction Steps

A mixture of the part A compound from Example 3 (100 mg, 0.26 mmol), phenyl boronic acid (48 mg, 0.39 mmol), a solution of aqueous 2.0 M sodium bicarbonate (380 μl, 0.76 mmol) and tetrakis(triphenylphosphine) palladium(0) (1 mg, 0.86 μmol) in degassed DME (1.5 mL) was heated at 90° C. for 18 h under nitrogen. The mixture was diluted with ethyl acetate (20 mL), washed with a solution of aqueous saturated sodium bicarbonate (3×20 mL), dried over sodium sulfate and concentrated. The crude product was purified by ISCO flash chromatography (silica gel/hexane-ethyl acetate 100:0 to 0:100 gradient) to afford the title compound as a white solid (45 mg, 45% yield).

Provenance & Evidence