Formamide → HCID 17990022, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 mL round-bottom flask was placed 3.5 g (11.75 mmol, 1 equiv) of 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3,6-dicarboxylic acid diethyl ester in 10 mL of formamide. The flask was equipped with a reflux condenser and heated at 140° C. for 16 h. The mixture was then allowed to cool to rt and a brown solid precipitated from solution. The resulting precipitate was filtered and rinsed with EtOAc (200 mL) and dried in a hi-vac oven for 2 h. After drying 3.25 g (99%) of the desired product as a brown solid was obtained and used without further purification in the next step. LCMS RT=2.80 min; [M+H]+=279.

Provenance & Evidence