Potassium Carbonate → 4-Methyl-2-oxo-4-phenylpentanoic acid ethyl ester

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Reaction Steps

10.0 g of 2-phenyl-2-propanol and 30.4 g of 2-(trimethylsilyloxy)acrylic acid-ethyl ester (Bull. Chem. Soc. Jpn. 1992, 65, 3209) are introduced into 386 ml of CH2Cl2 and treated at −70° C. with 11.5 ml of tin tetrachloride. After 15 minutes at −70° C., the batch is introduced into semiconcentrated potassium carbonate solution, extracted with CH2Cl2, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with ethyl acetate-cyclohexane yields 4.64 g of the product as a colorless oil.

Provenance & Evidence