HRID1293050

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13110446

未命名化合物

结构：CC(=O)OC[C@H]1O[C@@H](n2cnc3c(Cl)nc(C#N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O

HCID22948625

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccc(C)cc4)c4ccc(C)cc4)nc(C#N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O

HCID60018597

未命名化合物

PROCEDURE

实验过程

The compound was prepared from (2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(6-chloro-2-cyano-9H-purin-9-yl)tetrahydro-3-furanyl acetate (Preparation 45) and 2,2-bis(4-methylphenyl)ethanamine (J. Med. Chem., 1969, 12(1), 9) using a similar method to that of Preparation 64.

WORKUP

后处理

customof Preparation 64

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-80afd2a056904761885b62dd73e96578
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07238676B2
来源说明: uspto-grants-2007_07

反应 SMILES

[C:1]([O:4][C@H:5]1[C@@H:9]([O:10][C:11](=[O:13])[CH3:12])[C@H:8]([N:14]2[CH:22]=[N:21][C:20]3[C:15]2=[N:16][C:17]([C:24]#[N:25])=[N:18][C:19]=3Cl)[O:7][C@@H:6]1[CH2:26][O:27][C:28](=[O:30])[CH3:29])(=[O:3])[CH3:2].[CH3:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]([C:41]2[CH:46]=[CH:45][C:44]([CH3:47])=[CH:43][CH:42]=2)[CH2:39][NH2:40])=[CH:34][CH:33]=1>>[C:1]([O:4][C@H:5]1[C@@H:9]([O:10][C:11](=[O:13])[CH3:12])[C@H:8]([N:14]2[CH:22]=[N:21][C:20]3[C:15]2=[N:16][C:17]([C:24]#[N:25])=[N:18][C:19]=3[NH:40][CH2:39][CH:38]([C:35]2[CH:34]=[CH:33][C:32]([CH3:31])=[CH:37][CH:36]=2)[C:41]2[CH:46]=[CH:45][C:44]([CH3:47])=[CH:43][CH:42]=2)[O:7][C@@H:6]1[CH2:26][O:27][C:28](=[O:30])[CH3:29])(=[O:3])[CH3:2]